成分股SAGE Therapeutics收跌19.58%，Adaptive Biotechnologies跌11.27%，Wave Life Sciences、23Andme Holding Co.、Arcturus Therapeutics Holdings Inc.、Ventyx Biosciences跌8.94%-7.98%；Reneo Pharmaceuticals则收涨7.27%，Alx Oncology Holdings涨10.97%，Marinus Pharma涨20.00%，Vanda Pharmaceuticals也涨29.38%。
